Gene description for EPCAM |
Gene name |
epithelial cell adhesion molecule |
Gene symbol |
EPCAM |
Other names/aliases |
Ber-Ep4 BerEp4 DIAR5 EGP-2 EGP314 EGP40 ESA HNPCC8 KS1/4 KSA LYNCH8 M4S1 MIC18 MK-1 MOC-31 TACSTD1 TROP1 |
Species |
Homo sapiens |
Experiment description of studies that identified EPCAM in Breast cancer cells |
1
|
Experiment ID | 216 |
Identified molecule | protein
|
Extracellular vesicle type | Exosomes |
MISEV | EVs |
Identification method | Dot blot
|
PubMed ID |
21293856
|
Organism | Homo sapiens |
Experiment description | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC |
Authors | Battke C, Ruiss R, Welsch U, Wimberger P, Lang S, Jochum S, Zeidler R |
Journal name |
Cancer Immunol Immunother
|
Publication year | 2011 |
Sample | Breast cancer cells |
Sample name | BT474 |
Isolation/purification methods | Differential centrifugation Filtration Ultrafiltration Ultracentrifugation Sucrose density gradient |
Flotation density | 1.13-1.17 g/mL |
Molecules identified in the study | Protein |
Methods used in the study | Western blotting Immunoelectron microscopy FACS Dot blot |
EV-TRACK |
EV110080: EV-METRIC:14%, 14%, 38%
|
|
|
2
|
Experiment ID | 576 |
Identified molecule | protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | EVs |
Identification method | Mass spectrometry [LTQ]
|
PubMed ID |
27894104
|
Organism | Homo sapiens |
Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
Journal name |
Oncotarget
|
Publication year | 2016 |
Sample | Breast cancer cells |
Sample name | HS 578T |
Isolation/purification methods | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectrometry [LTQ] |
EV-TRACK |
-
|
|
|
3
|
Experiment ID | 577 |
Identified molecule | protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | EVs |
Identification method | Mass spectrometry [LTQ]
|
PubMed ID |
27894104
|
Organism | Homo sapiens |
Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
Journal name |
Oncotarget
|
Publication year | 2016 |
Sample | Breast cancer cells |
Sample name | MCF7 |
Isolation/purification methods | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectrometry [LTQ] |
EV-TRACK |
-
|
|
|
4
|
Experiment ID | 578 |
Identified molecule | protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | EVs |
Identification method | Mass spectrometry [LTQ]
|
PubMed ID |
27894104
|
Organism | Homo sapiens |
Experiment description | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. |
Authors | Hurwitz SN, Rider MA, Bundy JL, Liu X, Singh RK, Meckes DG Jr. |
Journal name |
Oncotarget
|
Publication year | 2016 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Polymer-based precipitation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectrometry [LTQ] |
EV-TRACK |
-
|
|
|
5
|
Experiment ID | 1255 |
Identified molecule | protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | EVs |
Identification method | Mass spectrometry
|
PubMed ID |
24468161
|
Organism | Homo sapiens |
Experiment description | Molecular characterization of exosome-like vesicles from breast cancer cells. |
Authors | Kruger S, Abd Elmageed ZY, Hawke DH, Wör PM, Jansen DA, Abdel-Mageed AB, Alt EU, Izadpanah R. |
Journal name |
BMC Cancer.
|
Publication year | 2014 |
Sample | Breast cancer cells |
Sample name | MDA-MB231 |
Isolation/purification methods | Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation |
Flotation density | - |
Molecules identified in the study | Protein miRNA |
Methods used in the study | Mass spectrometry Microarray RT-PCR Western blotting |
EV-TRACK |
EV140357: EV-METRIC:22%
|
|
|
6
|
Experiment ID | 3514 |
Identified molecule | protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Thermophoretic aptasensor (TAS)
|
PubMed ID |
30948809
|
Organism | Homo sapiens |
Experiment description | Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers |
Authors | Liu C, Zhao J, Tian F, Cai L, Zhang W, Feng Q, Chang J, Wan F, Yang Y, Dai B, Cong Y, Ding B, Sun J, Tan W. |
Journal name |
Nat Biomed Eng
|
Publication year | 2019 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Filtration Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Thermophoretic aptasensor (TAS) |
EV-TRACK |
-
|
|
|
7
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
8
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
9
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
10
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
11
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
12
|
Experiment ID | 1758 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry Western blotting |
EV-TRACK |
-
|
|
|
13
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|
14
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|
15
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|
16
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|
17
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|
18
|
Experiment ID | 1760 |
Identified molecule | Protein
|
Extracellular vesicle type | Extracellular vesicles |
MISEV | Small EVs |
Identification method | Mass spectrometry
|
PubMed ID |
35918900
|
Organism | Homo sapiens |
Experiment description | Characterization of protein complexes in extracellular vesicles by intact extracellular vesicle crosslinking mass spectrometry (iEVXL) |
Authors | Bauzá-Martinez J, Armony G, Pronker MF, Wu W. |
Journal name |
J Extracell Vesicles
|
Publication year | 2022 |
Sample | Breast cancer cells |
Sample name | MDA-MB-231 |
Isolation/purification methods | Differential centrifugation Ultracentrifugation |
Flotation density | - |
Molecules identified in the study | Protein |
Methods used in the study | Mass spectometry |
EV-TRACK |
-
|
|
|